Cialis History – How the Drug was Invented, Developed, and Released

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Cialis pillsCialis is considered one of the most powerful medical remedies for treating problems with sexual problems, including erectile dysfunction and prostate enlargement (or BPH, which, undoubtedly, can affect intimate life). This drug inspires trust to users all over the world, because of its high quality and efficiency. It has been on the pharmaceutical market for a long time, but the beginning of its history traces back to 1990s.

What Is Cialis and How It Was Discovered?

Cialis is a medicament that belongs to the group of PDE5 inhibitors. The mechanism of its action implies the inhibition of the enzyme PDE5 which adversely affects the blood flow in the genital area. Unlike other medications to treat male impotence, Cialis can be used both on demand (before sexual intercourse) and on an everyday basis (“as needed” option).

Cialis is available in several dosages:

  1. 2.5 mg. This dosage is usually used to treat mild ED. As a rule, men consume 2.5 mg of tadalafil when they were prescribed daily treatment option.

  2. 5 mg. This dosage can be used to treat ED and enlargement of the prostate simultaneously (on a daily basis). But it can also be prescribed by a healthcare professional for the use on demand.

  3. 10 mg. This is a typical dosage for using as needed.

  4. 20 mg. This dosage is usually used on demand, because it is too large to be used on a daily basis.

Before Cialis appearance, Viagra was considered the top medication for treatment erectile dysfunctions of any severity. Only 5 years after the release of Viagra FDA gave approval to the newly appeared ED medication (Cialis).

The story telling how Cialis’s production began merits your attention. Icos, Cialis’ inventor and developer of the medication, had been working on IC351 since 1993. Due to that procedure, the effect of ED medications was proved. By some quirk of fate, Pfizer, Viagra’s producer, discovered in 1994 that the drug, which enhanced erection, was created for treating heart diseases. Pfizer company managed to conduct the necessary clinical trials and release its medication on the market more quickly.

Cialis Development Process

TadalafilIcos managed to secure a patent for the IC351 ingredient in 1994. However, the studies focused on the action of this medication began in 1990. Nevertheless, it remained unclear whether the approval of the patent took place before or after Pfizer’s discovery of its own medicine. In 1997, the conducting of tests on men suffering from problems with erection begun. For Icos it was the second stage, which lasted almost 2 years until they started their final phase.

It is interesting to note that Eli Lilly and Icos merged to promote Cialis as a remedy for handling ED in the pharmaceutical market. In 2000, the drug initially called “IC351” was renamed into Cialis – the name which became world famous. It was the official “birthday” of Cialis. In May 2002, the developers of the drug reported its excellent effect due to its ability to remain in the male body for thirty-six hours. Six months later, Cialis was approved in most European countries where it started to gain its incredible popularity.

Cialis Research Data (Before Release)

Scientists conducted many studies that were necessary to obtain permission and to release the medicine to the pharmaceutical market. Initially, they conducted research on animals. Studies involving patients with erectile problems (the so-called phase 2 of clinical trials) began in 1997. One of published studies was the work of American scientists H. Padma-Nathan, who reported in 2001 that tadalafil at a dosage of 25 mg is a safe and effective medicine for the treatment of erectile dysfunction. In 2002, H. Porst and others presented that the medication is effective for up to 1.5 days.

In the spring of 2002, the first reports regarding the effectiveness and prolonged duration of action of tadalafil for impotence were reported at the Annual Meeting of the US Urological Association in Florida.

Release of Cialis to the US Pharmaceutical Market

eli lilly cialisThe medicament was approved for erectile problems treatment in European counties in late 2002. The process of approval of the drug in the US took more time. On 21 November, 2003, Icos and Eli Lilly obtained support for producing Cialis and received the necessary patent in the USA. Cialis quickly gained popularity due to its undeniable advantages. Now the volume of sales of the branded version of Cialis is comparable with the sales volume of Viagra, the main competitor of Cialis.

Nowadays, most users appreciate Cialis for its numerous advantages and consider it more efficient than Viagra. First of all, Generic Cialis is famous for its prolonged action, which lasts 36 hours, as distinct from Viagra’s short-term impact. It makes Cialis the ED drug, which helps consumers save both money and time. In spite of the fact that Viagra is currently more recognizable, Cialis is gaining popularity every day. And who knows, perhaps, in some years, it will turn into the most demanded ED drug on the pharmaceutical market.

Updated: March 29, 2018 by: admin